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In vitro studies have demonstrated that primarily metabolism by CYP3A4 results in the sulphone metabolite, and further metabolism by 2C19 results in desmethyl rabeprazole.

  • In order to assess the relief from heartburn and from other symptoms of GERD after 3 days of treatment with standard-dose rabeprazole or high-dose omeprazole, healing rates and quantification of antacid use, Holtmann et al (2002) studied 230 patients with endoscopically confirmed erosive esophagitis that were randomized to receive 4 weeks of double-blind treatment with rabeprazole (20 mg) or omeprazole (40 mg).
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