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Trileptal is the brand name for the generic drug oxcarbazepine, a prescription drug used to treat seizures and epilepsy in adults and children over 2 years old.
Trileptal is in a group of drugs called anticonvulsants or antiepileptic drugs, which work by decreasing nerve impulses that cause seizures.
This drug is also prescribed off-label to treat migraines, nerve pain, and some mood disorders such as bipolar disorder.
Generic oxcarbazepine was developed in Europe in the 1960s, but wasn’t approved for use by the Food and Drug Administration (FDA) in the United States until 2000.
Trileptal is manufactured by Novartis Pharmaceuticals, while the generic oxcarbazepine has several manufacturers.
Oxcarbazepine is also generic for the brand-name drug Oxtellar XR.
In 2010, the U.S.
Department of Justice filed charges against Novartis for illegally marketing Trileptal as a psychiatric or pain-management drug.
Trileptal only has FDA approval as an antiepileptic.
(It’s against the law to promote other uses not authorized by the FDA).
Novartis pled guilty to a misdemeanor charge and agreed to pay $442.5 million to settle the case.
Trileptal Warnings Trileptal can reduce your body’s sodium to dangerously low levels.
This can cause a life-threatening electrolyte imbalance.
The FDA reports that Trileptal may cause suicidal thoughts or actions in a very small number of people (about 1 in 500).
This is common among many antiepileptic medications.
Never stop taking this drug without talking to your doctor.
Stopping a seizure medication can cause an epilepsy patient to experience status epilepticus (seizures that will not stop).
Patients with significant kidney problems could develop serious complications on this drug.
Discuss your mental history with your physician, including if you’ve had suicidal thoughts or actions, depression, or mood problems in the past.
Other prior health issues that may be a concern if you are considering taking Trileptal are liver and kidney problems.
Your doctor also needs to know about any allergies you have, and about all the medications you take, whether prescription or over-the-counter (OTC), vitamins, illegal or recreational drugs, and dietary or herbal supplements, as they can affect how Trileptal works, and vice-versa.
Pregnancy and Trileptal Trileptal may make birth control pills less effective.
Trileptal may harm an unborn baby, so tell your doctor immediately if you get pregnant while taking this drug.
If you are pregnant, planning a pregnancy or breastfeeding, tell your doctor before starting Trileptal.
The FDA advises that women who are breastfeeding should not to take this drug.
BasicDescription Back to Top Trileptal Side Effects Trileptal may cause your sodium levels to drop dangerously low.
Symptoms of low sodium include: Nausea Tiredness Lack of energy Headache Confusion More frequent or severe seizures Similar symptoms that are not related to low sodium may occur when taking this drug, so it’s important to tell your doctor everything you are feeling to make sure it’s not serious.
Trileptal can cause suicidal thoughts in some people.
Talk to your doctor if you experience a new or deepening depression, thoughts of hurting yourself or suicide, panic attacks, anxiety, abrupt mood changes or sudden hyperactivity, if you’re acting aggressive or violent, have trouble sleeping or if you feel like acting on dangerous impulses Common Side Effects of Trileptal Changes in vision Difficulty with walking or balance Dizziness and headache Jerky or uncoordinated movement Stomach upset or pain Nausea and vomiting Excessive sleepiness and fatigue Tremor Serious Side Effects of Trileptal Swelling of your lips, face, eyes, or tongue Trouble swallowing or breathing A skin rash Hives Fever Swollen glands Fever that comes and goes Sores around the mouth or eyes Yellowing of the eyes or skin Unusual bruising or bleeding Extreme weakness Frequent or persistent infections Back to Top Trileptal Interactions Talk to your doctor if you take a calcium channel blocker, other seizure control medication or elvitegravir/cobicistat, an HIV combination drug.
This medication can make you drowsy so taking other medications that cause drowsiness could double the effect.
Tell your doctor if you take medicine for sleep, anxiety, sedatives, narcotic pain relievers, muscle relaxers, psychiatric medications, or an antihistamine that causes drowsiness.
Also check over-the-counter (OTC) cough and cold products since they often contain ingredients that cause you to feel sleepy.
The following medications can interact with Trileptal: Amiodarone (Cordarone) Amlodipine ( Norvasc ) Felodipine (Plendil) Nifedipine (Procardia) Nimodipine (Nimotop) Verapamil (Calan, Covera, Isoptin, Verelan ) Cyclosporine Lansoprazole ( Prevacid ) Omeprazole ( Prilosec ) Pantoprazole (Protonix) Citalopram (Celexa) Sertraline ( Zoloft ) This is not a complete list of drugs that interact with Trileptal.
Give your healthcare provider a complete list of all the prescription drugs, including OTC medications, vitamins, supplements, and any illegal or recreational drugs.
Trileptal and Alcohol Trileptal can increase drowsiness so it’s best to avoid alcohol.
Back to Top Trileptal Dosage Your dosage depends on the severity of your condition so your doctor will decide the strength that’s right for you.
This medication is a tablet or a suspension (liquid) taken by mouth, usually twice a day.
The extended release tablet (Oxtellar XR) is taken once daily.
This drug can be taken with or without food.
It’s important to space doses evenly and take it on time to keep the level of medication in your blood consistent.
Never stop taking this drug without telling your doctor.
Abruptly stopping Trileptal could cause your seizures to get much worse.
Trileptal Overdose In case of overdose, call a poison control center at 1-800-222-1222, go to an emergency room, or call 911.
Missed Dose of Trileptal If you miss a dose, take it as soon as you remember unless it’s close to the time of your next dose.
Never take a double dose.
Back to Top Trileptal Pictures Trileptal 150 mg, yellow, oblong Oxcarbazepine 150 mg-APO, yellow, oval Oxcarbazepine 150 mg-ROX, peach, round Oxcarbazepine 150 mg-TEV, orange, oblong Oxcarbazepine 600 mg-APO, yellow, oblong Oxcarbazepine 600 mg-ROX, peach, oblong Oxcarbazepine 600 mg-TEV, orange, oblong Trileptal 600 mg, yellow, oblong, film coated Oxcarbazepine 300 mg-ROX, peach, round Oxcarbazepine 300 mg-TEV, orange, oblong Trileptal 300 mg, yellow, oblong, film coated Oxcarbazepine 300 mg-APO, yellow, oval

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