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Lioresal is a prescription drug used to treat muscle spasms from multiple sclerosis and Huntington’s disease as well as spinal cord injuries and spinal cord diseases.
Medical experts do not recommend baclofen for muscle spasms caused by rheumatoid arthritis, cerebral palsy, Parkinson’s disease, or stroke, because research to date does not support such use.
Lioresal is an antispastic muscle relaxant.
Researchers don’t know exactly how baclofen works; however, in general, it blocks nerve signals from muscles at the level of the spinal cord and it may also depress the central nervous system.
The Food and Drug Administration (FDA) approved baclofen in 1977 under the brand name Lioresal, which was made by Novartis.
The FDA approved generic baclofen in the 1980s.
Today, only generic versions of baclofen are available.
A case report published in Therapeutic Advances in Psychopharmacology in 2014 suggested that baclofen might be effective for treating marijuana dependence, particularly for those who have used the drug heavily for a long time.
The research also showed that baclofen may help reduce withdrawal symptoms as well as the effects of marijuana.
A separate study, published in the Journal of Neuroscience in 2014, found that baclofen may also help people with drug addiction avoid possible triggers and prevent relapse.
The drug works by interfering with the brain’s early response to drug cues.
Lioresal Pump You can take baclofen as a pill or via an intrathecal baclofen (ITB) pump.
In ITB therapy, your doctor will insert a small catheter under the skin of your abdomen, near your waist.
The pump stores and releases the prescribed amount of baclofen through the catheter, using a small motor, directly into your spinal fluid.
ITB can be an option for people who experience side effects taking baclofen in pill form as it requires smaller doses of the drug and thus keeps side effects to a minimum.
Your doctor will need to refill your ITB pump system every one to three months.
Combination of carbamazepine with lamotrigine or baclofen is the second-line treatment when monotherapy fails, but the evidence for this polypharmacy is scant.
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