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Ondansetron is a prescription medication used to prevent nausea and vomiting caused by chemotherapy or surgery. Ondansetron belongs to a group of drugs called serotonin 5-HT3 antagonists, which block serotonin, a natural chemical in the body, from causing nausea and vomiting.
This medication comes in several oral forms: tablets, orally disintegrating (dissolving) tablets, an oral soluble film, and solution (liquid). Ondansetron is also available in an injectable form to be given directly into a vein (IV) by a healthcare professional.
The first oral dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery.
Common side effects include headache, tiredness, and constipation. Ondansetron can cause dizziness. Do not drive or operate heavy machinery until you know how it affects you.
Ondansetron is a prescription medication used for the:
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Ondansetron may be found in some form under the following brand names:
Ondansetron is part of the drug class:
Ondansetron can cause serious side effects. See “Drug Precautions” section.
This is not a complete list of ondansetron side effects. Ask your doctor or pharmacist for more information.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
This is not a complete list of ondansetron drug interactions. Ask your doctor or pharmacist for more information.
Serious side effects have been reported with ondansetron including :
Ondansetron can cause drowsiness. Do not drive or operate heavy machinery until you know how ondansetron affects you.
Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of ondansetron, there are no specific foods that you must exclude from your diet when receiving this medication.
Before taking ondansetron, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories – A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Ondansetron falls into category B. There are no good studies that have been done in humans with ondansetron. But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.
It is not known if ondansetron crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using ondansetron.
Take ondansetron exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
The recommended ondansetron dose for preventing nausea and vomiting after surgery is 16 mg taken one hour before anesthesia is administered.
High-risk (for nausea and vomiting) chemotherapy: The dose of ondansetron for high-risk chemotherapy is 24 mg 30 minutes before chemotherapy.
Medium-risk (for nausea and vomiting) chemotherapy: The dose of ondansetron for medium-risk chemotherapy is ondansetron 8 mg twice daily.
The recommended oral dosage of ondansetron is one 8 mg given 3 times a day.
Total body irradiation: The dose of ondansetron for total body irradiation is 8 mg taken one to two hours before radiotherapy each day of radiation treatment.
Single high-dose fraction radiotherapy to the abdomen: The recommended dose is 8 mg taken one to two hours before radiotherapy followed by 8 mg every eight hours until one to two days after radiation.
Daily fractionated radiotherapy to the abdomen: The recommended dose is 8 mg taken each day one to two hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day radiotherapy is given.
Dose in Patients with Liver Disease
The dose of ondansetron is decreased for people who have poor liver function (hepatic function). People with severely impaired liver function should not take more than 8 mg ondansetron total each day.
If you take too much ondansetron, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.
Keep this and all medications out of the reach of children.

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