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One may think that the infection has been completely cured by anti-malarial treatment, and be feeling fully recovered, however, sustained long-term accumulation of parasite by-products leave the bone in a state of chronic inflammation, leading to long term bone loss.Oral supplementation with alfacalcidol, a vitamin D3 analog, could completely prevent bone loss.

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  • Additionally, compliance with alfacalcidol therapy in the pulse group was complete during the study as patients received their pulse dose of alfacalcidol at the end of each dialysis session and this was given b y nursing staff in the hemodialysis unit.
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